Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency Running title: CARD9 deficiency in neutrophils
نویسندگان
چکیده
1 Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands 2 Department of Experimental Immunology, Academic Medical Center, Amsterdam 3 Division of Pediatric Neurology, Centre Hospitalier de Luxembourg, Luxembourg 4 Division of Pediatric Endocrinology, Centre Hospitalier de Luxembourg, Luxembourg 5 Division of Cell Biology, Dutch Cancer Institute, Amsterdam, The Netherlands 6 Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands * shared first author
منابع مشابه
Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency.
Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule in the cytosol of myeloid cells, required for induction of T-helper cells producing interleukin-17 (Th17 cells) and important in antifungal immunity. In a patient suffering from Candida dubliniensis meningoencephalitis, mutations in the CARD9 gene were found to result in the loss of protein expression. Apart from the...
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Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in the C-type lectin pathway adaptor protein CARD9 develop spontaneous fungal disease that targets the central nervous system (CNS). However, how CARD9 promotes protective antifungal immunity in the CNS remains unclear. Here, we show that a patien...
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Invasive pulmonary aspergillosis is a life-threatening mycosis that only affects patients with immunosuppression, chemotherapy-induced neutropenia, transplantation, or congenital immunodeficiency. We studied the clinical, genetic, histological, and immunological features of 2 unrelated patients without known immunodeficiency who developed extrapulmonary invasive aspergillosis at the ages of 8 a...
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Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor proteins CARD9 and MyD88 via C-type lectin, Toll-like, and interleukin-1 family receptor signals, defining the temporal and spatial pattern of MyD88- and CARD9-coupled signals in immune activation and fungal clearance has been difficult to achi...
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